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KMID : 0374019880110020105
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Ewha Medical Journal
1988 Volume.11 No. 2 p.105 ~ p.119
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The Protective Effect of Mannitol, Steroid, Phenytoin and Barbiturates on Experimental Acute Focal Cerebral Ischemia
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Abstract
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The authors have studied the therapeutic effect of the combinations of mannitol, methylprednisolone (MP), phenytoin and barbiturates on the acute focal cerebral ischemia (AFCI) in cats. The experimental animals. were divided into three groups. Group I was the cats with the removal of the orbital contents without occlusion of MCA Group 11 was that of 2-hour recirculation after AFCI following the occlusion of MCA for 3 hours. Group C was subdivided into four subgroups as Group 111-a, Group IlI-b, Group Ill-c and Group IlI-d. Group Ill-a was that of treatment of combinations of mannitol and MP, Group Ill-b that of combinations of mannitol and phenytoin, Group Ill-c that of combinations of mannitol and barbiturates, and Group III-d that of combinations of mannitol, MP (60mg/kg) phenytoin and barbiturates. As the biochemical studies cytochrome oxidase activities (COA) and the concentrations of lipid peroxidation (LP) were determined, and as the pathohistologic studies the degree of the infarcted areas, hemispheric swellings and the comparative microscopic findings of the infarcted areas were studied.
In Group Ill-a and Group III-b no therapeutic effect on the AFCI was presented. In Group 111-c the partial effect of brain protection were demonstrated only in LP and the degree of hemispheric swelling, but Group 111-d provided nearly complete protection from ischemic damage.
These experimental data suggested that the medical measures of the combinations of mannitol, MP, phenytoin and barbiturates can make the AFCI fully reversible and would be applicable in the clinical field.
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